Inositol Phosphates and Calcium Signalling (Advances in Second Messenger and Phosphoprotein Research)
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Inositol Phosphates and Calcium Signalling (Advances in Second Messenger and Phosphoprotein Research)

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Published by Lippincott Williams & Wilkins .
Written in English


  • Cellular biology,
  • Neurosciences,
  • Pharmacology,
  • Life Sciences - Biochemistry,
  • Nucleotides,
  • Science,
  • Health/Fitness

Book details:

The Physical Object
Number of Pages416
ID Numbers
Open LibraryOL11224455M
ISBN 10088167883X
ISBN 109780881678833

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  Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In Cited by: Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP 3 or Ins3P or IP 3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC). Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in CAS Number: Discovery of the InsP₃-Ca² pathway: a personal reflection / Michael J. Berridge --G-protein: regulated prospholipase C: identification of component proteins / T. Kendall Harden --Multiple forms of phospholipase C isozymes and their activation mechanisms / Sue Goo Rhee and Kang Duk Choi --Metabolism of inositol phosphates / Stephen B. Shears. Metabolism of myo -Inositol Phosphates and the Alternative Pathway in Generation of myo -Inositol Trisphosphate Involved in Calcium Mobilization in Plants Susweta Biswas, B. B. Biswas Pages Phosphoinositide Turnover and Its Role in Plant Signal Transduction.

Calcium imaging of single cells has begun to reveal that this inositol 1,4,5-trisphosphate/calcium signaling system is organized in complex patterns, which include localization of calcium signals to discrete regions of cells and the generation of both calcium waves and calcium oscillations. (JAMA. ;). Inositol trisphosphates act on the inositol triphosphate receptor to release calcium into the cytoplasm. Further reading: Function of calcium in humans Other. Inositol tetra-, penta-, and hexa-phosphates have been implicated in gene expression. Inositol hexaphosphate. Inositol hexaphosphate facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. Nishizuka Y. Calcium, phospholipid turnover and transmembrane signalling. Philos Trans R Soc Lond B Biol Sci. Jul 5; ()– Nishizuka Y. Turnover of inositol phospholipids and signal transduction. Science. Sep 21; ()– Nishizuka Y. The effect of inositol 1,4,5 trisphosphate (IP3) on calcium mobilization was studied in human osteosarcoma lines, Saos-2 and G, as well as isolated rat osteoblastic and osteoclastic cells. Cells were permeabilized with saponin and calcium mobilization was studied with the fluorescent dye, fura-2 in a recording spectrofluorometer. IP3 (10 μM) increased calcium release in all cell types studied.

55 rows  Inositol phosphates are important intracellular second messengers in eukaryotic cells. .   Published on Lesson on the Inositol Trisphosphate (IP3) and Calcium Signaling Pathway. IP3, calcium and diacylglycerol (DAG) are important second messengers that are unregulated upon. Inositol tetrakis phosphate (inositol-P 4) participates in calcium homeostasis in some systems, but the generality of this effect is unclear. Inositol-P 5 and inositol-P 6 have been proposed as extracellular agonists that augment neuronal excitability and reduce heart rate and blood pressure, but it is not clear how these compounds might exit.   ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism Yann Desfougèresa, Miranda S. C. Wilsona, Debabrata Lahaa, Gregory J. Millerb, and Adolfo Saiardia,1 aMedical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT London, United Kingdom; and bDepartment of Chemistry, The Catholic University .